The Role of Cancer-Associated Fibroblasts
Pancreatic adenocarcinoma (PDAC) stands out as one of the most aggressive forms of cancer, characterized by a complex stroma that comprises nearly 80% of the tumor mass. A significant contributor to this dense stroma is the presence of cancer-associated fibroblasts (CAFs). These specialized cells not only support tumor growth but also play a pivotal role in immune suppression, drug resistance, and metastasis.
Understanding the Stroma and Its Components
At the core of the tumor microenvironment is fibronectin (FN), a principal component produced by CAFs. This protein forms a scaffold that integrates with other matrix proteins to create a rigid, fibrotic extracellular matrix (ECM). This matrix is essential for establishing and maintaining the tumor’s architecture, which directly influences tumor initiation and progression.
Targeting CAFs to Combat Pancreatic Cancer
Strategically disrupting the CAFs’ ability to assemble and uphold their supportive matrix offers a promising pathway for combating the stemness and progression of pancreatic cancer. By inhibiting this process, it may be possible to reduce the aggressive nature of PDAC and improve therapeutic outcomes for patients. Unlocking such strategies not only provides hope for more effective treatment approaches but also emphasizes the importance of targeting the interaction between CAFs and their matrix.